Ipamorelin 2mg

Name: Ipamorelin 2mg
SKU: PL-2MG-PG01
Price: 30.00 USD
Availability: InStock

Brands PeptideLion

$30.00

out of stock

Sku:

PL-2MG-PG01

Brands: PeptideLion

Description

Overview:

What is Ipamorelin?

Ipamorelin is a peptide that has been shown to increase growth hormone levels in humans by stimulating the hypothalamus, which is responsible for regulating the secretion of growth hormone. Ipamorelin works by binding to IGF-1 receptors in the body and mimicking its effects on those receptors. This causes an increase in muscle mass and strength, as well as fat loss due to increased metabolism and lipolysis (the breakdown of fat).

Benefits of Ipamorelin:

Decreased body fat
Increased collagen production
Increased lean muscle mass
Improved sleep
Increased cellular repair and regeneration
Increased IGF-1
Increases bone mineral content
Counteracts glucocorticoid catabolic effects
Less appetite stimulation than GHRP-6
Less release of cortisol, prolactin, and aldosterone

Ipamorelin has been shown to be highly potent and has also demonstrated good safety and tolerability in human clinical studies. It is also helpful in boosting metabolism, regulating appetite and energy levels, enhancing cell regeneration, and improving overall well-being.

Scientific Information:

The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described. Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo. As an outcome of a major chemistry programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth hormone-releasing peptide (GHRP)-1. In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%). A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml). In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma). GHRP-2 displayed higher potency but lower efficacy (ED50 = 0.6 nmol/kg and Emax = 56+/-6 ng GH/ml plasma). The specificity for GH release was studied in swine. None of the GH secretagogues tested affected FSH, LH, PRL or TSH plasma levels. Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation. This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED50 for GH release. In conclusion, ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH. The specificity of ipamorelin makes this compound a very interesting candidate for future clinical development.

Research Highlights:

Ipamorelin is one of the latest and greatest peptides in the growth factor family. Deemed one of the safest GHRPs, Ipamorelin is a selective growth hormone (GH) Secretagogue and Ghrelin receptor agonist. This peptide generates similar increases in growth hormone secretion, but without appetite stimulation and an increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class.

It should be emphasized that Ipamorelin is not only the most efficient but also the safest and selective GH stimulant. That’s because Ipamorelin stimulates growth hormones without having an effect on the blood levels of prolactin and cortisol. This feature makes Ipamorelin attractive for bodybuilders, and why it is arguably the best option from among all peptides stimulating the GH production.