CJC-1295 (DAC) 5mg
$56.00
out of stock
Description
CJC-1295 (DAC), also known as ‘the growth hormone’, is a synthetic peptide fragment (177-191) derived from the C-terminus of the human growth hormone (hGH). Research shows that it can stimulate GH production and has anti-aging properties.
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Read on to learn more about the benefits of CJC-1295 peptides and supporting research.
What is CJC-1295?
CJC-1295 is a synthetic peptide that can stimulate the release of growth hormone (GH) from the pituitary gland. It incorporates a functional maleimide group at the C-terminus, allowing it to bind plasma proteins such as serum albumin. These CJC-1295-protein conjugates aka CJC-1295 (DAC) have a much greater half-life compared to the unconjugated peptide. They can stimulate GH production for more than six days in humans after a single administration.
How is CJC-1295 different from CJC-1295 (DAC)?
The addition of DAC in CJC-1295 alters its pharmacokinetics, extends its half-life, and maintains the release of growth hormone over an extended period. CJC-1295 (DAC) has a longer half-life, requiring less frequent dosage and administration than CJC-1295. The DAC is added to CJC-1295 through a lysine linker to make it safe while it streams in the blood.
Here are the potential CJC-1295 (DAC) benefits:
- Requires less frequent dosing
- Promotes muscle growth
- Enhances muscle recovery process
- Improves skin texture and elasticity, removes wrinkles
- Increases energy levels
- Aids in weight loss
Note: The CJC-1295 (DAC) peptide is an experimental compound intended for research purposes only. It is not FDA-approved for therapeutic use or human consumption. However, it has been tested on humans in clinical trials; therefore, it is essential to consult a healthcare professional before taking it.
CJC-1295 (DAC) Peptide Structure and Properties
- Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys-DAC
- Molecular formula: C165H269N47O46
- Molar mass: 3647.250 g·mol−1
- Safety and Tolerability: While CJC-1295 DAC is well-tolerated, the most common side effects of CJC-1295 DAC are mild and include redness, swelling, or itching at the injection site.
- Synthetic design: CJC-1295 is derived from the 29-amino-acid sequence of GHRH (Growth Hormone-Releasing Hormone) but extends this sequence to 30 amino acids for added functionality. The design enhances its ability to bind GHRH receptors in the anterior pituitary, effectively stimulating natural growth hormone (GH) release. The pairing of CJC-1295 with DAC makes it more stable, increases its half-life, and enhances its ability to stimulate GH production.
- Half-life: The estimated half-life of CJC-1295 (DAC) is 5.8 to 8.1 days.
- Dosage and administration: CJC-1295 (DAC) is administered as a subcutaneous injection, typically 1-2 mg weekly or biweekly.
For scientists working on anti-aging peptides, PeptideLion is one of the best CJC-1295 suppliers because we ensure both the quality and the consistency of our peptides.
CJC-1295 Research Summary
2006: CJC-1295 and its effect on GH and IGF-I
A clinical trial was conducted on CJC-1295 to assess the pharmacodynamics and safety of CJC-1295. They conducted two random double-blind trials of 28 and 49 days, respectively. Healthy participants in the age range of 21-61 years were selected for single or multiple doses of CJC-1295. There was a 2- to 10-fold increase in mean plasma GH concentrations due to a single dose for 6 days and a 1.5- to 3-fold raise in IGF-I for 9–11 days. After multiple CJC-1295 doses, mean IGF-I levels remained above baseline for up to 28 d. No serious adverse reactions were reported. This study validates that CJC-1295 enhances GH and IGF-I secretions.
2006: CJC-1295 and Pulsatile Secretion of Growth Hormone (GH)
A study in 2006 elaborates on the effects of a single injection of CJC on GH pulsatility as well as the parameters of GH secretion that correlate with the increase in IGF-I production. Healthy men between 20 and 40 years were observed before and after an injection of CJC-1295 (60 to 90). GH pulsatility was assessed by 20-min blood sampling during an overnight 12-h period. Results showed that mean GH was increased by 46% while IGF-I rose by 45%, and it does
- Sam L. Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne, Lawrence A. Frohman, Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults, The Journal of Clinical Endocrinology & Metabolism, Volume 91, Issue 3, 1 March 2006, Pages 799–805
not correlate with GH pulsatility parameters. This study validates the clinical usage of CJC-1295 to enhance GH and IGF-I production.
2016: Can females use CJC-1295?
In 2016, researchers used “netnography” – a research form to evaluate online consumer culture – to extract the possibilities of CJC-1295 use in females. They conducted a systematic internet search using the term “CJC-1295” and combined it with “forum.” Ninety-six bodybuilding websites mentioned CJC-1295. When they narrowed the research, 9 websites mentioned CJC-1295 for female use. The forum participants seemed informative and experienced in the poly use of performance and image drug supplementation. The main reasons for taking CJC-1295 were muscle growth, weight loss, youthful skin, improved sleep, and injury healing.
Summary
CJC-1295 is a promising peptide therapy due to its potential anti-aging properties. It helps stimulate the production of GH, promoting tissue regrowth, muscle recovery, and skin healing. CJC-1295 peptides have shown much safety and efficacy in early human trials. However, further research is still needed to understand its pros and cons fully.
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2. Madalina Ionescu, Lawrence A. Frohman, Pulsatile Secretion of Growth Hormone (GH) Persists during Continuous Stimulation by CJC-1295, a Long-Acting GH-Releasing Hormone Analog, The Journal of Clinical Endocrinology & Metabolism, Volume 91, Issue 12, 1 December 2006, Pages 4792–4797,
3. Van Hout, M. C., & Hearne, E. (2016). Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions. Substance Use & Misuse, 51(1), 73–84. https://doi.org/10.3109/10826084.2015.1082595
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