BPC-157 + TB500 5/5 MG
$120.00
in stock
Description
BPC 157 and TB500 are synthetic peptides for wound healing, tissue repair, anti-inflammatory, and angiogenetic properties. Despite having distinct mechanisms of action, the BPC157 TB500 blend is known to have a synergistic effect on tissue repair and healing.
BPC 157 and TB500 have overlapping properties. BPC 157 promotes the synthesis of nitric oxide and growth factors, reduces inflammation, and activates the cascade of reactions that support tissue repair and wound healing. TB500 focuses more on cell migration promoting healing and repair at a cellular level.
Looking to buy BPC 157 and TB500 blend? PeptideLion offers 99% pure, high-quality peptides best suited for your research needs. Read on to learn about their benefits and how they work.
Potential Benefits of BPC 157 and TB500 Blend
BPC 157 peptide is synthesized from a protective fragment of a naturally occurring gastric peptide. It is highly stable and resistant to the effects of gastric acids, hydrolysis, and digestion. The evidence from preclinical research has shown the following potential benefits of BPC 157:
- Accelerates wound healing and tissue repair
- Upregulates growth factors
- Improves tendon and ligament recovery
- Reduces inflammation
- Promotes regeneration of blood vessels
- Strengthens and repairs endothelial lining
TB 500 or thymosin beta 4 is a regenerative peptide with potent wound healing benefits. The compound focuses primarily on migrating cells involved in tissue healing and recovery, keratinocytes, and collagen to the injury site. Potential TB500 benefits include:
- Skin healing and repair
- Accelerates wound healing
- Upregulates deposition of keratinocytes and collagen at the injury site
- Accelerates healing in multiple injury models including traumatic brain injury, spinal cord injury, cardiac damage due to ischemia
- Promotes regeneration of blood vessels
- Reduces inflammation
Note: BPC 157 TB 500 blend is an experimental compound intended for research purposes only. It is not approved for therapeutic use or human consumption.
BPC-157 and TB500: Peptide Structure and Properties
- Sequence:
BPC 157: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
TB500: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
- Molecular formula:
BPC 157: C62H98N16O22
TB500: C38H68N10O14
- Molecular weight:
BPC 157: 1419.53552 g/mol
TB500: 889.01
- Properties of BPC 157 TB500 blend: BPC 157 is designed to remain stable and resistant to the effects of hydrolysis and gastric acids. It shows a dose-dependent relationship where higher or optimal BPC 157 dosages may enhance its biological benefits. On the other hand, TB500 stimulates the movement and sequestration of actin at the injury site, a protein responsible for muscle contraction and cell movement. The limited evidence from research shows that the combination of TB500 and BPC 157 might synergistically affect wound healing and tissue repair, making the blend particularly useful for people looking to heal sports injuries, chronic pains, muscle recovery, and enhance their physical performance.
- BPC 157 TB 500 blend dosage: The therapeutic dosage of BPC 157 and TB500 varies in different studies. Research on animal models has shown potential therapeutic benefits of BPC 157 with doses ranging from 10 to 40 µg/kg. However, there is no established BPC 157 TB500 blend dosage for humans. The dose might vary based on the condition treated, severity, body weight, and other factors.
- Administration: Injections are most common, the blend is also available in the form of BPC 157 TB 500 capsules, topical creams, and nasal sprays.
Research Summary
Venous Ulcers
A double-blind, placebo-controlled, randomized trial was conducted to assess the safety, tolerability, and efficacy of thymosin beta-4 in treating venous ulcers. A total of 73 participants were treated with Tbeta-4 or placebo. The results showed accelerated wound healing in 25% of the patients with mild to moderately severe wounds. BPC 157 can have therapeutic benefits in healing intestinal fistulas caused by the blockage of NO-synthase in rat models. Rats with esophageal fistulas were treated with BPC 157 (given parenterally and preorally) for four days. The treatment was done alone or in combination with L-NAME and I-arginine. The results showed that BPC 157 significantly accelerated fistula healing, reduced leakage, restored sphincter pressure, and eliminated the risk of esophagitis. No fatalities were recorded in rats treated with BPC 157.
Wound healing
Animal studies in wounded rats show that topical or intraperitoneal administration of TB500 accelerated wound healing. It enhanced the process of skin repair, migration of repair cells, and collagen deposition at the damaged site. It increased the migration of keratinocytes by 2-3 folds, making it a potent wound-healing peptide. Another study evaluated the skin healing benefits of BPC 157(PL14736) in healthy and experimental hyperglycemic rats. Gel formulation of the compound was applied to excision skin wounds, while a PDGF gel was applied as a standard therapy. The healing process was observed and recorded for 7 days. They reported that BPC 157 showed a dose-dependent acceleration of wound healing in diabetic rats. In addition, it was more effective in depositing granulation tissues and mature collagen as compared to the standard therapy.
Myocardial cell survival
A randomized, placebo-controlled trial showed the therapeutic benefits of thymosin beta-4 in promoting myocardial cell survival during acute myocardial infarction. A total of 40 participants were included in 4 cohorts. They showed that thymosin beta 4 promoted the survival of myocardial cells, and showed no adverse outcomes or dose-related toxicities.
Summary
Regenerative peptides like BPC 157 and TB500 and their ability to accelerate wound healing have sparked the interest of many researchers. While BPC 157
- Guarnera, G., DeRosa, A., Camerini, R., & 8 European sites (2010). The effect of thymosin treatment of venous ulcers. Annals of the New York Academy of Sciences, 1194, 207–212. https://doi.org/10.1111/j.1749-6632.2010.05490.x
- Cesarec, V., Becejac, T., Misic, M., Djakovic, Z., Olujic, D., Drmic, D., Brcic, L., Rokotov, D. S., Seiwerth, S., & Sikiric, P. (2013). Pentadecapeptide BPC 157 and the esophagocutaneous fistula healing therapy. European journal of pharmacology, 701(1-3), 203–212. https://doi.org/10.1016/j.ejphar.2012.11.055
- Malinda, K. M., Sidhu, G. S., Mani, H., Banaudha, K., Maheshwari, R. K., Goldstein, A. L., & Kleinman, H. K. (1999). Thymosin beta4 accelerates wound healing. The Journal of investigative dermatology, 113(3), 364–368. https://doi.org/10.1046/j.1523-1747.1999.00708.x
- Seveljević-Jaran, D., Cuzić, S., Dominis-Kramarić, M., Glojnarić, I., Ivetić, V., Radosević, S., & Parnham, M. J. (2006). Accelerated healing of excisional skin wounds by PL 14736 in alloxan-hyperglycemic rats. Skin pharmacology and physiology, 19(5), 266–274. https://doi.org/10.1159/000093982
- Ruff, D., Crockford, D., Girardi, G., & Zhang, Y. (2010). A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. Annals of the New York Academy of Sciences, 1194, 223–229. https://doi.org/10.1111/j.1749-6632.2010.05474.x
promotes and stimulates actin production – a key protein in cellular movement, contraction, and signaling, TB 500 sequesters it at the site of injury. The BPC 157 TB500 blend upregulates growth hormones, promotes new blood vessel formation, accelerates wound healing, and enhances cell migration and sequestration of actin. This in turn makes it an ideal combination to deal with soft tissue injuries, tissue regeneration, and wound healing.
Looking to buy BPC 157 and TB500 blend?
At Peptide Lion, we deal in 99% pure peptides that produce reliable, reproducible, and accurate results when it comes to research. Explore our website to get your hands on BPC 157 TB500 – our ultimate injury recovery and tissue repair peptide blend. Click here to buy now!
